dachopper

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About dachopper

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  1. dachopper

    Sydney to Hobart 2020

    Dare I ask..... was the foiling 50 footer finished?
  2. dachopper

    First Effective Treatment Imminent

    Your right on that one for now, not just them, all Donor stem cell companies and the FDA. Lets see how the Type A meeting goes at the beginning of November still could turn out to be a world first.
  3. dachopper

    First Effective Treatment Imminent

    That was the same product, but for a different treatment. I wouldn't be surprised if there is litigation involved if it's not sorted next month. Safe product that saved childrens lives in the last trial, but FDA doesn't understand or believe the company understands how it works so they decide not to approve it. Pity for the children that have no alternative ! It will certainly muddy the waters if the COVID trial comes back also positive and safe, and the FDA blocks it for the same reason. They even disagreed with their own panel of experts who voted 9 to 1 that it works, and told the company there is no evidence it works. Clearly - there must be a hidden agenda there!
  4. dachopper

    First Effective Treatment Imminent

    Good timing, they announced the trial is 45% complete now with recommendation due first week of November, and full enrollment now estimated by December.
  5. dachopper

    Garmin Watch users - new Sailing Datafield

    Version 3.2 now out, Race Countdown auto screen sequence upgrade - will take you directly to the start line waypoint drop screen and out again
  6. dachopper

    First Effective Treatment Imminent

    You welcome the state of affairs, the lockdowns, the travel bans, the millions of deaths that have occurred as a result of this ? You are nuts. It's not a problem faced by this company alone, there are other options that are equally delayed months / years / decades because of the draconian science measures, and the almost mandatory placebo controlled trial.....Really in the 21st century we have to treat some people with saline and then watch them die before we can say - ok this works. Yay for human kind. Why can't a single arm trial be acceptable in the 21st century. On face value under normal circumstances that don't involve the entire earth stopping then many months of testing might be acceptable, but they are talking about injecting a novel bio-active substance that came from within a person, and resides within all people, that has a perfect safety record, an understood mechanism of action after over 2000 injections in children / adults and the elderly.....after over 10 years of research & development. It's not battery acid or bleach or some other concocted molecule, or vaccine made be humans, placed into a virus in a lab I mean if you have ever received a live blood transfusion you would have received some of these cells by default. When the drug proves that it does save people, yet hundreds of thousands have died wile it was going through yet more rounds of clinical trials... who exactly are the ignorant people that held up a safe therapy that didn't give a fuck about about killing people ????? The FACT is for this company, this drug already has pre-existing FDA Fast Track Designation before covid. It's due to be approved for use and for sale in the USA by the end of September this month. That is the same drug they now have to do more trials, full double blind placebo control randomised trials for. I dare say, had the FDA said a single arm would be sufficient that it would already be completed by now. When you are on deaths bed and the prognosis is that you will most likely die, and you have been offered an experimental treatment where there is a 50% chance you will receive saline and die.... there are a lot of people that would try and pick a different trial that has no saline arm, and there are thousands of trials trying different therapies / vaccines available without a placebo control. https://www.globenewswire.com/news-release/2020/02/03/1978576/0/en/Mesoblast-Submits-Completed-Biologics-License-Application-for-Ryoncil-to-US-FDA.html
  7. dachopper

    First Effective Treatment Imminent

    It is a sad state of affairs in the 21st Century where the quickest state of the art treatment takes 6 months to go through an approval process.... meanwhile potentially the lockdown fate of most of the world is waiting... Pluristem are expecting to finish enrollment for their stem cell PHASE 2 trial by the end of Q1 in 2021 Athersys who had already tested their treatment successfully for ARDS in a phase 1/2 trial that finished in May 2019 ( before Covid ), Started their COVID ARDS trial at the same time as Mesoblast, and are expecting it to finish Primary end points in September 2021 Mesoblast has stated they expect primary completion by the end of Q4 2020, with a possible early termination at the 30/45/60% mark also an option. They will still be first to the pin by a country mile... you can't rush evidence though I'm afraid. Too many people think it's snake oil and need to be proven beyond 95% that it isn't.
  8. dachopper

    First Effective Treatment Imminent

    Well - they have the drug available along with manufacturing so they are ready to hand it out.... Next opportunity for FDA to approval will most likely come in October at the 45% trial mark. If it demonstrates superior efficacy, then the trial will be halted and it will be immediately approved. Given the USA and many other places are now going into winter, cases are set to rise again and they should find recruitment faster hopefully. To show superior efficacy at 45%, they don't just need to change the mortality rate by a small amount, they need a huge difference something like a 40% difference. So if 60% on placebo die. then if under 20% die that were treated, it may classify for superior efficacy. Ie, it reduces the mortality rate by something like 60% or greater. That is what is expected based off the initial emergency access results too by the way. They are also one of the few treatments approved for, and have treated children with MISC who have recovered abnormally well afterwards.
  9. dachopper

    First Effective Treatment Imminent

    Interesting interview with the CEO, talks about the COVID-19 trial around the 4 minute mark. Sounds like they want the trial to go the full distance rather than stop early ( or at least are planning for it). Currently more that 30% complete.
  10. dachopper

    Garmin Watch users - new Sailing Datafield

    It's really up to you, I had the fenix 5 before the 6 and the things that I didn't like about the 5 was the battery life ( although it still looks about twice as good as the venu ) and that it did not support wireless music - both improved along with the display looks great on the 6. At the end of the day as long as it does what you want it to do, then that's all that matters. This page looks pretty good for comparing the stats https://www.comparebeforebuying.com/garmin-venu-vs-fenix-6/ I don't like the battery life of the Venu ( only 6 hours with gps ? ) , I'm not sure about the display readability in the sun only because the fenix is mentioned as sunlight visible? The rest looks similar. For reference - I charged my fenix about 4 days ago, it's telling me I have 18 days battery left and I'm wearing it every day. It never misses a beat ! The fenix 5x vs fenix 6, is about double the battery life, you can pickip fenix 5X online for a discount now that the 6 is out if you are worried about the battery - it has 12 hours gps, but no music
  11. dachopper

    Garmin Watch users - new Sailing Datafield

    It depends what you use the watch for, you pay for what you get. The Fenix is definitely top of the range for sure..... If your trying to read the display, the fenix is nearly 20% bigger, doesn't sound like much but if you are banging around on the water, 20% will make it harder to read
  12. dachopper

    Garmin Watch users - new Sailing Datafield

    Sorry it's unsupported now. I believe you can edit the standard boating datafield on your watch now inside the boating app - which was not possible when I wrote the original datafield, but now you can get the same info in almost the same format. If your happy maybe give that a try? The only downside to my app, and any aftermarket app that is not garmin - is that garmin will not share the watch waypoint or course list, which means every navigation based app, needs to use it's own list, or it's just a datafield and piggybacks onto something like the boating app.
  13. dachopper

    Garmin Watch users - new Sailing Datafield

    User video guide on the download page https://apps.garmin.com/en-US/apps/1980c826-844a-47f7-9ca8-ffc0e09ba2ba
  14. dachopper

    Garmin Watch users - new Sailing Datafield

    Sail Racer Version 3.0 is released and still free in the connect iq store., now supports race starts. What you get - existing pre race countdown timer, with ability to update the countdown if slightly off by re-clicking start when the flag/gun drops. Above countdown is your speed to the nearest end if off the ends of the line. If sailing below the startline your VMG to the closest point is displayed. At the bottom of the screen is speed required directly to the nearest point of the line, to arrive at the nearest part of the line at time = zero. Concept, make the two speeds match and you will nail the start every time. Requires accurately setting wind axis in the start area through menu-set wind. Then a sail past both ends of the start line after entering race countdown mode. Watch will display " set start a", approaching 1 end , 1 boat length bellow the line click start. Then repeat at the other end of the line to " set start b". Then required speed will show once countdown started at the bottom. "req 2.5 kt", and boatspeed or VMG if downwind of the line at the top of the screen. Enjoy!
  15. dachopper

    First Effective Treatment Imminent

    Data Monitoring Committee has recommended Mesoblast continue the trial, meaning they did not see safety issues or signs of probable futility. My guess for the next meeting is the first week of October we will be getting the 45% complete DMC meeting. https://www.asx.com.au/asxpdf/20200904/pdf/44mb8dlw20vxv2.pdf