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dachopper

First Effective Treatment Imminent

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3 minutes ago, MR.CLEAN said:

Any day now.

Look at this chart I copied from “imminent phase 3” trial from back in February showing everything is awesome and imminent cure!

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1 hour ago, Albatros said:

im·mi·nent | \ ˈi-mə-nənt

\

Definition of imminent

 

: ready to take place : happening soon

Well - they have the drug available along with manufacturing so they are ready to hand it out....

 

Next opportunity for FDA to approval will most likely come in October at the 45% trial mark. If it demonstrates superior efficacy, then the trial will be halted and it will be immediately approved. Given the USA and many other places are now going into winter, cases are set to rise again and they should find recruitment faster hopefully.

 

To show superior efficacy at 45%, they don't just need to change the mortality rate by a small amount, they need a huge difference something like a 40% difference. So if 60% on placebo die. then if under 20% die that were treated, it may classify for superior efficacy.  Ie, it reduces the mortality rate by something like 60% or greater. That is what is expected based off the initial emergency access results too by the way. 

 

They are also one of the few treatments approved for, and have treated children with  MISC who have recovered abnormally well afterwards.

 

 

 

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^^^^^^^^^^^^^^^^^^^^^^

Vogon poetry is the third worst in the Universe. The second worst is that of the Azgoths of Kria, and the worst is by Paula Nancy Millstone Jennings of Sussex, who perished along with her poetry during the destruction of Earth, ironically caused by the Vogons themselves. Vogon poetry is seen as mild by comparison.

Oh freddled gruntbuggly,
Thy micturations are to me, (with big yawning)
As plurdled gabbleblotchits, in midsummer morning
On a lurgid bee,
That mordiously hath blurted out,
Its earted jurtles, grumbling
Into a rancid festering confectious organ squealer. [drowned out by moaning and screaming]
Now the jurpling slayjid agrocrustles,
Are slurping hagrilly up the axlegrurts,
And living glupules frart and stipulate,
Like jowling meated liverslime,
Groop, I implore thee, my foonting turlingdromes,
And hooptiously drangle me,
With crinkly bindlewurdles,mashurbitries.
Or else I shall rend thee in the gobberwarts with my blurglecruncheon,
See if I don't!
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9 minutes ago, Albatros said:

^^^^^^^^^^^^^^^^^^^^^^

Vogon poetry is the third worst in the Universe. The second worst is that of the Azgoths of Kria, and the worst is by Paula Nancy Millstone Jennings of Sussex, who perished along with her poetry during the destruction of Earth, ironically caused by the Vogons themselves. Vogon poetry is seen as mild by comparison.

Oh freddled gruntbuggly,
Thy micturations are to me, (with big yawning)
As plurdled gabbleblotchits, in midsummer morning
On a lurgid bee,
That mordiously hath blurted out,
Its earted jurtles, grumbling
Into a rancid festering confectious organ squealer. [drowned out by moaning and screaming]
Now the jurpling slayjid agrocrustles,
Are slurping hagrilly up the axlegrurts,
And living glupules frart and stipulate,
Like jowling meated liverslime,
Groop, I implore thee, my foonting turlingdromes,
And hooptiously drangle me,
With crinkly bindlewurdles,mashurbitries.
Or else I shall rend thee in the gobberwarts with my blurglecruncheon,
See if I don't!

Where is my damn towel??  

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It is a sad state of affairs in the 21st Century where the quickest state of the art treatment takes 6 months to go through an approval process.... meanwhile potentially the lockdown fate of most of the world is waiting...

 

Pluristem are expecting to finish enrollment for their stem cell PHASE 2 trial by the end of Q1 in 2021

Athersys  who had already tested their treatment successfully for ARDS in a phase 1/2 trial that finished in May 2019 ( before Covid ), Started their COVID ARDS trial at the same time as Mesoblast, and are expecting it to finish Primary end points in September 2021

Mesoblast has stated they expect primary completion by the end of Q4 2020, with a possible early termination at the 30/45/60% mark also an option.

 

They will still be first to the pin by a country mile... you can't rush evidence though I'm afraid. Too many people think it's snake oil and need to be proven beyond 95% that it isn't.   :)

 

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^^^^^^

"Bleem miserable venchit! Bleem forever mestinglish asunder frapt.
Gashee morphousite, thou expungiest quoopisk!
Fripping lyshus wimbgunts, awhilst moongrovenly kormzibs.
Gerond withoutitude form into formless bloit, why not then? Moose."
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7 hours ago, dachopper said:

It is a sad state of affairs in the 21st Century where the quickest state of the art treatment takes 6 months to go through an approval process.... meanwhile potentially the lockdown fate of most of the world is waiting...

Pluristem are expecting to finish enrollment for their stem cell PHASE 2 trial by the end of Q1 in 2021

Athersys  who had already tested their treatment successfully for ARDS in a phase 1/2 trial that finished in May 2019 ( before Covid ), Started their COVID ARDS trial at the same time as Mesoblast, and are expecting it to finish Primary end points in September 2021

Mesoblast has stated they expect primary completion by the end of Q4 2020, with a possible early termination at the 30/45/60% mark also an option.

 

They will still be first to the pin by a country mile... you can't rush evidence though I'm afraid. Too many people think it's snake oil and need to be proven beyond 95% that it isn't.   :)

 

What a perfectly welcome state of affairs it is that the proposed injection of novel bio-active substances - for profit - into human bodies takes many, many months of rigorous investigation, testing, and proving before it is acceptable for use on a global scale. 

Pump and dump specialists may disagree.

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7 hours ago, dachopper said:

It is a sad state of affairs in the 21st Century where the quickest state of the art treatment takes 6 months to go through an approval process

Only if you don't give a fuck about killing patients and only care about stock price.

 

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2 minutes ago, MR.CLEAN said:

Only if you don't give a fuck about killing patients and only care about stock price.

 

And 6 months isn’t even true - the data just isn’t there to support a rapid approval. If his claims from his first post were actually grounded in fact, we would have heard about positive results and approval in about 60 days. Now he’s claiming there aren’t enough patients for a double blind and keeps repeating percentage points till completion like he’s rendering a video and the % fluctuates back and forth for unknown reasons. 

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STNG (Star Trek Next Generation) would need only hours, a day or two at most.  They would probably focus first on remediation instead of a vaccine.

Only in sci-fi, of course.  We have a long way to go and may never get there.

 

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7 hours ago, Albatros said:

^^^^^^^^^^^^^^^^^^^^^^

Vogon poetry is the third worst in the Universe. The second worst is that of the Azgoths of Kria, and the worst is by Paula Nancy Millstone Jennings of Sussex, who perished along with her poetry during the destruction of Earth, ironically caused by the Vogons themselves. Vogon poetry is seen as mild by comparison.

Oh freddled gruntbuggly,
Thy micturations are to me, (with big yawning)
As plurdled gabbleblotchits, in midsummer morning
On a lurgid bee,
That mordiously hath blurted out,
Its earted jurtles, grumbling
Into a rancid festering confectious organ squealer. [drowned out by moaning and screaming]
Now the jurpling slayjid agrocrustles,
Are slurping hagrilly up the axlegrurts,
And living glupules frart and stipulate,
Like jowling meated liverslime,
Groop, I implore thee, my foonting turlingdromes,
And hooptiously drangle me,
With crinkly bindlewurdles,mashurbitries.
Or else I shall rend thee in the gobberwarts with my blurglecruncheon,
See if I don't!

And here I thought it Rudyard Kipling's:

Take up the White Man's burden—
    Send forth the best ye breed—
Go bind your sons to exile
    To serve your captives' need;
To wait in heavy harness
    On fluttered folk and wild—
Your new-caught, sullen peoples,
    Half devil and half child.

Take up the White Man's burden—
    In patience to abide,
To veil the threat of terror
    And check the show of pride;
By open speech and simple,
    An hundred times made plain.
To seek another's profit,
    And work another's gain.

Take up the White Man's burden—
    The savage wars of peace—
Fill full the mouth of Famine
    And bid the sickness cease;
And when your goal is nearest
    The end for others sought,
Watch Sloth and heathen Folly
    Bring all your hopes to nought.

Take up the White Man's burden—
    No tawdry rule of kings,
But toil of serf and sweeper—
    The tale of common things.
The ports ye shall not enter,
    The roads ye shall not tread,
Go make them with your living,
    And mark them with your dead!

Take up the White Man's burden—
    And reap his old reward:
The blame of those ye better,
    The hate of those ye guard—
The cry of hosts ye humour
    (Ah, slowly!) toward the light:—
"Why brought ye us from bondage,
    Our loved Egyptian night?"

Take up the White Man's burden—
    Ye dare not stoop to less—
Nor call too loud on Freedom
    To cloak your weariness;
By all ye cry or whisper,
    By all ye leave or do,
The silent, sullen peoples
    Shall weigh your Gods and you.

Take up the White Man's burden—
    Have done with childish days—
The lightly proffered laurel,
    The easy, ungrudged praise.
Comes now, to search your manhood
    Through all the thankless years,
Cold-edged with dear-bought wisdom,
    The judgment of your peers!

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5 hours ago, Left Shift said:

What a perfectly welcome state of affairs it is that the proposed injection of novel bio-active substances - for profit - into human bodies takes many, many months of rigorous investigation, testing, and proving before it is acceptable for use on a global scale. 

Pump and dump specialists may disagree.

You welcome the state of affairs, the lockdowns, the travel bans, the millions of deaths that have occurred as a result of this ? You are nuts.

It's not a problem faced by this company alone, there are other options that are equally delayed months / years / decades because of the draconian science measures, and the almost mandatory placebo controlled trial.....Really in the 21st century we have to treat some people with saline and then watch them die before we can say - ok this works. Yay for human kind. Why can't a single arm trial be acceptable in the 21st century. 

 

On face value under normal circumstances that don't involve the entire earth stopping then many months of testing might be acceptable, but they are talking about injecting a novel bio-active substance that came from within a person, and resides within all people, that has a perfect safety record, an understood mechanism of action after over 2000 injections in children  / adults and the elderly.....after over 10 years of research & development. It's not battery acid or bleach or some other concocted molecule, or vaccine made be humans, placed into a virus in a lab

I mean if you have ever received a live blood transfusion you would have received some of these cells by default.

 

 When the drug proves that it does save people, yet hundreds of thousands have died wile it was going through yet more rounds of clinical trials... who exactly are the ignorant people that held up a safe therapy that didn't give a fuck about about killing people ?????

 

The FACT is for this company, this drug already has pre-existing FDA Fast Track Designation before covid.  It's due to be approved for use and for sale in the USA by the end of September this month. That is the same drug they now have to do more trials, full double blind placebo control randomised trials for.  I dare say, had the FDA said a single arm would be sufficient that  it would already be completed by now. When you are on deaths bed and the prognosis is that you will most likely die, and you have been offered an experimental treatment where there is a 50% chance you will receive saline and die.... there are a lot of people that would try and pick a different trial that has no saline arm, and there are thousands of trials trying different therapies / vaccines available without a placebo control.

https://www.globenewswire.com/news-release/2020/02/03/1978576/0/en/Mesoblast-Submits-Completed-Biologics-License-Application-for-Ryoncil-to-US-FDA.html  

 

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See, see the dachopper sky
Marvel at its big voidoid depths.
Tell me, covid do you
Wonder why the mumblefuck ignores you?
Why its foobly stare
makes you feel leek.
I can tell you, it is
Worried by your brumbleweed facial growth
That looks like
A azok.
What's more, it knows
Your babyborrel potting shed
Smells of warthog.
Everything under the big dachopper sky
Asks why, why do you even bother?
You only charm dachopper.

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Buffalo Bill's
        defunct
               who used to
               ride a watersmooth-silver
                                        stallion
        and break onetwothreefourfive pigeonsjustlikethat
                                                         Jesus
        he was a handsome man
                             and what i want to know is
        how do you like your blueeyed boy
        Mister Death

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