Plumbing a water system to function with suction is asking for trouble. Here at the cabin and on the boat plumbing for gravity priming of pumps makes a world of difference regardless of what the overly optimistic pump datasheets say. Sometime one has no choice....
Air is about 1000 times...
Some minimal accumulator is a requirement. Some pumps have a small one built in. Without gravity, like in a land-side tanked system, there must be give somewhere or when the pump stops the system pressure will go to zero. That's physics....water is incompressible. Maybe stretchy tubing is...