First Effective Treatment Imminent

Left Shift

Super Anarchist
10,528
3,274
Seattle
^^^^^^^^^^^^^^^^^^^^^^

Vogon poetry is the third worst in the Universe. The second worst is that of the Azgoths of Kria, and the worst is by Paula Nancy Millstone Jennings of Sussex, who perished along with her poetry during the destruction of Earth, ironically caused by the Vogons themselves. Vogon poetry is seen as mild by comparison.



Oh freddled gruntbuggly,


Thy micturations are to me, (with big yawning)


As plurdled gabbleblotchits, in midsummer morning


On a lurgid bee,


That mordiously hath blurted out,


Its earted jurtles, grumbling


Into a rancid festering confectious organ squealer. [drowned out by moaning and screaming]


Now the jurpling slayjid agrocrustles,


Are slurping hagrilly up the axlegrurts,


And living glupules frart and stipulate,


Like jowling meated liverslime,


Groop, I implore thee, my foonting turlingdromes,


And hooptiously drangle me,


With crinkly bindlewurdles,mashurbitries.


Or else I shall rend thee in the gobberwarts with my blurglecruncheon,


See if I don't!
And here I thought it Rudyard Kipling's:

Take up the White Man's burden—
    Send forth the best ye breed—
Go bind your sons to exile
    To serve your captives' need;
To wait in heavy harness
    On fluttered folk and wild—
Your new-caught, sullen peoples,
    Half devil and half child.

Take up the White Man's burden—
    In patience to abide,
To veil the threat of terror
    And check the show of pride;
By open speech and simple,
    An hundred times made plain.
To seek another's profit,
    And work another's gain.

Take up the White Man's burden—
    The savage wars of peace—
Fill full the mouth of Famine
    And bid the sickness cease;
And when your goal is nearest
    The end for others sought,
Watch Sloth and heathen Folly
    Bring all your hopes to nought.

Take up the White Man's burden—
    No tawdry rule of kings,
But toil of serf and sweeper—
    The tale of common things.
The ports ye shall not enter,
    The roads ye shall not tread,
Go make them with your living,
    And mark them with your dead!

Take up the White Man's burden—
    And reap his old reward:
The blame of those ye better,
    The hate of those ye guard—
The cry of hosts ye humour
    (Ah, slowly!) toward the light:—
"Why brought ye us from bondage,
    Our loved Egyptian night?"

Take up the White Man's burden—
    Ye dare not stoop to less—
Nor call too loud on Freedom
    To cloak your weariness;
By all ye cry or whisper,
    By all ye leave or do,
The silent, sullen peoples
    Shall weigh your Gods and you.

Take up the White Man's burden—
    Have done with childish days—
The lightly proffered laurel,
    The easy, ungrudged praise.
Comes now, to search your manhood
    Through all the thankless years,
Cold-edged with dear-bought wisdom,
    The judgment of your peers!

 

dachopper

Super Anarchist
1,268
33
What a perfectly welcome state of affairs it is that the proposed injection of novel bio-active substances - for profit - into human bodies takes many, many months of rigorous investigation, testing, and proving before it is acceptable for use on a global scale. 

Pump and dump specialists may disagree.
You welcome the state of affairs, the lockdowns, the travel bans, the millions of deaths that have occurred as a result of this ? You are nuts.

It's not a problem faced by this company alone, there are other options that are equally delayed months / years / decades because of the draconian science measures, and the almost mandatory placebo controlled trial.....Really in the 21st century we have to treat some people with saline and then watch them die before we can say - ok this works. Yay for human kind. Why can't a single arm trial be acceptable in the 21st century. 

On face value under normal circumstances that don't involve the entire earth stopping then many months of testing might be acceptable, but they are talking about injecting a novel bio-active substance that came from within a person, and resides within all people, that has a perfect safety record, an understood mechanism of action after over 2000 injections in children  / adults and the elderly.....after over 10 years of research & development. It's not battery acid or bleach or some other concocted molecule, or vaccine made be humans, placed into a virus in a lab

I mean if you have ever received a live blood transfusion you would have received some of these cells by default.

 When the drug proves that it does save people, yet hundreds of thousands have died wile it was going through yet more rounds of clinical trials... who exactly are the ignorant people that held up a safe therapy that didn't give a fuck about about killing people ?????

The FACT is for this company, this drug already has pre-existing FDA Fast Track Designation before covid.  It's due to be approved for use and for sale in the USA by the end of September this month. That is the same drug they now have to do more trials, full double blind placebo control randomised trials for.  I dare say, had the FDA said a single arm would be sufficient that  it would already be completed by now. When you are on deaths bed and the prognosis is that you will most likely die, and you have been offered an experimental treatment where there is a 50% chance you will receive saline and die.... there are a lot of people that would try and pick a different trial that has no saline arm, and there are thousands of trials trying different therapies / vaccines available without a placebo control.

https://www.globenewswire.com/news-release/2020/02/03/1978576/0/en/Mesoblast-Submits-Completed-Biologics-License-Application-for-Ryoncil-to-US-FDA.html  

 

Albatros

Super Anarchist
4,038
521
See, see the dachopper sky
Marvel at its big voidoid depths.
Tell me, covid do you
Wonder why the mumblefuck ignores you?
Why its foobly stare
makes you feel leek.
I can tell you, it is
Worried by your brumbleweed facial growth
That looks like
A azok.
What's more, it knows
Your babyborrel potting shed
Smells of warthog.
Everything under the big dachopper sky
Asks why, why do you even bother?
You only charm dachopper.

 

Ishmael

Super Antichrist
58,333
16,221
Fuctifino
Code:
Buffalo Bill's
        defunct
               who used to
               ride a watersmooth-silver
                                        stallion
        and break onetwothreefourfive pigeonsjustlikethat
                                                         Jesus
        he was a handsome man
                             and what i want to know is
        how do you like your blueeyed boy
        Mister Death
 

Miffy

Super Anarchist
3,834
1,700
I've been doing some research on the potential ways out of this lockdown mess and back to normality, and discovered the little Aussie company that could ( Mesoblast ) - are in the middle of a US trial that looks like it's as close to a guaranteed done deal in reducing Covid caused deaths as you can get before a trial end date. They have a treatment of cells that they were in the final  stages of getting approved for use in the USA targeting steroid refractive Graft verses Host disease - which there is no treatment for, and has all ready shown fantastic results ( GVHD is where your own immune system attacks / kills you after receiving a transplant. Steroids are the only treatment but they do not work in about 40% of cases   ). 

As it turns out - the main killing mechanism they observe from Covid , appears to be the Hyper immune response, and the body killing itself also ( cytokine storm ).

So far they have treated 12 people on compassionate grounds who were seriously ill, on ventilators, some with multiple organ failure, some on ventilators for 2 weeks solid prior to being treated, and had a recovery rate of 83% or 10 / 12 people.. The recovery rate in the hospital during that same period for ventilated patients was under 12% ( 88% died ).

They are now about 1 week into the final trial that is necessary to prove that the treatment works, as a proper medical trial with patients getting treated with maximum care standard + either placebo or the cells. The trial has a primary endpoint of survival at 30 days, and also at 7 and 14 days along with other measurements. 33% of the way through the trial, if it is observed that the treatment is overwhelming effective ( which is expected by the compassionate use and other data ) - Then the FDA can approve immediate treatment before the trial has completed.

What is interesting is that Mesoblast by co-incidence were already ramping up production of the cells massively in preparation of their US product launch Ryoncil, and they have stated that they are in a good position to be capable of treating as many critical patents as is needed.

They also have some different cells that are completing their last phase 3 trial next month for lower back pain ( disc regeneration ) / and heart failure which also both look like they are primed for excellent results. 

If they show with the large trial what they did with the 12 critically ill patients, then we are going to be reducing COVID deaths to a level lower than seasonal Flu.... Also the product can treat seasonal Flu aswell..... Fingers crossed we here good news by the end of the month. or some time in June.  
If I need a laugh I just quote the post that started it all that had the confidence of someone who admitted later he has no SME in biology, biomedical research or medicine. 

 

dachopper

Super Anarchist
1,268
33
Good timing, they announced the trial is 45% complete now with recommendation due first week of November, and full enrollment now estimated by December. 

 

SCARECROW

Super Anarchist
6,036
708
Melbourne, Aus
Great quote from the CEO

“Chief executive Silviu Itescu said he believed the request for more data would set the company's planned launch of the product back "somewhere in the order of 3 to 5 months".”

it certainly wasn’t going to speed it up.  Right up they with the weather girl saying we should have seen the last of the September rains on the news on September 30th.

 

dachopper

Super Anarchist
1,268
33
Great quote from the CEO

“Chief executive Silviu Itescu said he believed the request for more data would set the company's planned launch of the product back "somewhere in the order of 3 to 5 months".”

it certainly wasn’t going to speed it up.  Right up they with the weather girl saying we should have seen the last of the September rains on the news on September 30th.
That was the same product, but for a different treatment. I wouldn't be surprised if there is litigation involved if it's not sorted next month. Safe product that saved childrens lives in the last trial, but FDA doesn't understand or believe the company understands how it works  so they decide not to approve it. Pity for the children that have no alternative !

It will certainly muddy the waters if the COVID trial comes back also positive and safe, and the FDA blocks it for the same reason. They even disagreed with their own  panel of experts who voted 9 to 1 that it works, and told the company there is no evidence it works.

Clearly - there must be a hidden agenda there! 

 

El Borracho

Barkeeper’s Friend
7,171
3,083
Pacific Rim
Clearly - this is but one more in a long sad history of failures for Mesoblast. Press releases and stock bumping do not make a successful pharma company.

 
Last edited by a moderator:

dachopper

Super Anarchist
1,268
33
Clearly - this is but one more in a long sad history of failures for Mesoblast. Press releases and stock bumping do not make a successful pharma company.
Your right on that one for now, not just them, all Donor stem cell companies and the FDA. Lets see how the Type A meeting goes at the beginning of November still could turn out to be a world first.

 

jack_sparrow

Super Anarchist
37,393
5,094
Let's hope you didn't sink Granny's pension into it, and that you are young enough to recover from being the 490 millionth person to get suckered by a pharmaco.
Clean you will love this.

State sponsored insider trading.


Click to continue.

 

dachopper

Super Anarchist
1,268
33
Yep - 45% DMC readout next week. 

Fingers crossed it works because plainly nothing else has. 

Unfortunately for them to stop the trial this early though - they will need something like 60% + controls mortality,  and under 10% treated mortality. Otherwise will need to wait for the 60 or full treatment to finish  

 

El Borracho

Barkeeper’s Friend
7,171
3,083
Pacific Rim
Yep - 45% DMC readout next week. 

Fingers crossed it works because plainly nothing else has.
First Effective Lawsuit Imminent! The pump and dumpers will get to explain their lies in court:

LAWSUITS FILED AGAINST MESO

The filed complaint alleges that defendants made materially false and/or misleading statements and/or failed to disclose that: (1) comparative analyses between Mesoblast's Phase 3 trial and three historical studies did not support the effectiveness of the Company's lead product candidate, remestemcel-L, for steroid refractory acute graft versus host disease due to design differences between the four studies...

 

Miffy

Super Anarchist
3,834
1,700
I'm kind of chuckling at how this thread was so obviously bullshit from the get go - "random guy with admittedly no basic biology, medicine or clinical trial exp" says he found a "little australian company that could" blah blah blah stem cell imminent blah blah blah done deal. Posts bunch of unrelated studies and some even from within the PRC BEFORE covid19 was even publicly acknowledged as human to human transmission. 

lol

 

jack_sparrow

Super Anarchist
37,393
5,094
And he didn't listen.  :lol:

IMG_20201106_031943.jpg

 
Last edited by a moderator:
Top