First Effective Treatment Imminent

[dachopper]

More interesting is if US prepared to let manufacturer off the liability hook and leave it's citizens carrying all the risk. 

Hey who gives a fuck then if approvals might be a bit rushed. 

Coronavirus vaccine: Pfizer given protection from legal action by UK government

"TheThe Department of Health and Social Care has confirmed the company has been given an indemnity protecting it from legal action as a result of any problems with the vaccine."

Then the Govt indemnify themselves. 

4th bullet point and the exemption 

   View attachment 411335

I don't blame them - look what happened with the swine flue vaccine. Now governments all over the world are successfully being forced to compensate all the people now stuck with narcolepsy.

 

[Miffy]

I don't blame them - look what happened with the swine flue vaccine. Now governments all over the world are successfully being forced to compensate all the people now stuck with narcolepsy.

lol you read one article about Sweden and now "governments all over the world are being forced to compensate all the people"

 

[ProaSailor]

There is a treatment for Covid-19 but only for the wealthy.

Giuliani says he didn't know most Americans can't access his VIP coronavirus treatment regimen, DECEMBER 9, 2020
https://www.salon.com/2020/12/09/giuliani-says-he-didnt-know-most-americans-cant-access-trumps-vip-coronavirus-treatment-regimen/

Like Trump, Giuliani has been treated with remdesivir and dexamethasone, which one of the radio hosts pointed out is too expensive for ordinary Americans.

"I, well, I didn't know that. I mean, they give it to us here at this hospital," Giuliani told the radio hosts.
[...]
After being diagnosed with COVID-19, Trump was given the steroid dexamethasone to address his lowered oxygen levels; a five-day course of the antiviral drug remdesivir that is meant to improve recovery time for patients; and an 8 gram dose of an experimental drug called REGN-COV2 from the biotechnology company Regeneron.

The treatment that President Trump got is certainly not available to all patients, Dr. Georges Benjamin, executive director of the American Public Health Association, told Salon by email in October. Benjamin's views were echoed at the time by Dr. Richard D. Wolff, professor emeritus of economics at the University of Massachusetts Amherst.

"Privilege is the key adjective to describe not only the medical care Trump is now receiving but the entire package of first-rate health care provided freely to top officials, the Congress, etc," Wolff wrote to Salon. 

 

[dachopper]

I think dexamethasone  and REGN-COV2 are probably the best options out there currently on the treatment front * if they are available. With the discovery of long covid symptoms recently though and long term side effects, I am waiting patiently for msb to finish their trial. The benefit for all being that their treatment is regenerative and hopefully will stop long covid symptoms all together, unlike single use therapies like dexameth or antibodies.

 

[dachopper]

Well.....  This isn't such good news, unlikely to reduce mortality by 43% - actual mortality reduction is unknown.

Trial has been halted at about 75% enrolled, results will be now unblinded after mid February - hopefully it shows some form of efficacy and they can correlate why it started out showing good efficacy, but then reduced for patients enrolled Oct - Nov.

Still worth keeping an eye on.

http://investorsmedia.mesoblast.com/static-files/bc0ce366-1c50-46ce-a9d4-d06b7ce403e5

 

[Albatros]

imminent

 

[ProaSailor]

Three days ago the FDA approved the first over-the-counter COVID-19 test.  Why were vaccines developed and approved more quickly than this test?

Coronavirus (COVID-19) Update: FDA Authorizes Antigen Test as First Over-the-Counter Fully At-Home Diagnostic Test for COVID-19, December 15, 2020
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-antigen-test-first-over-counter-fully-home-diagnostic

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the first over-the-counter (OTC) fully at-home diagnostic test for COVID-19. The Ellume COVID-19 Home Test is a rapid, lateral flow antigen test, a type of test that runs a liquid sample along a surface with reactive molecules. The test detects fragments of proteins of the SARS-CoV-2 virus from a nasal swab sample from any individual 2 years of age or older. 

“Today’s authorization is a major milestone in diagnostic testing for COVID-19. By authorizing a test for over- the-counter use, the FDA allows it to be sold in places like drug stores, where a patient can buy it, swab their nose, run the test and find out their results in as little as 20 minutes,” said FDA Commissioner Stephen M. Hahn, M.D. 

But the fine print explains the intrusive string attached - Big Brother gets your test results!!

Test results from your product will be automatically reported to relevant public health
authorities, via your product’s software application (app), in accordance with local, state, and
federal requirements, using appropriate LOINC and SNOMED codes, as defined by the
“Laboratory In Vitro Diagnostics (LIVD) Test Code Mapping for SARS-CoV-2 Tests”
provided by the Centers for Disease Control and Prevention (CDC).

Your product includes a single use Analyzer and a single use sampling and processing system
that includes a sterile Nasal Swab with a child adapter, Processing Fluid, and a Dropper. To use
your product the user must first download the Ellume COVID-19 Home Test App for iOS or
Android phones. The user follows the instructions on the Quick Start Guide included in the kit
box to connect the Analyzer to their phone. The user then views an informational video and
follows the in-app self-paced, step-by-step instructions to complete the test.

 

[BlatantEcho]

Three days ago the FDA approved the first over-the-counter COVID-19 test.  Why were vaccines developed and approved more quickly than this test?

Coronavirus (COVID-19) Update: FDA Authorizes Antigen Test as First Over-the-Counter Fully At-Home Diagnostic Test for COVID-19, December 15, 2020
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-antigen-test-first-over-counter-fully-home-diagnostic

But the fine print explains the intrusive string attached - Big Brother gets your test results!!

Of course they do.

What's freedom?

 

[dachopper]

Of course they do.

What's freedom?

Being able to test positive and then run around infecting other people as much as you like ?

 

[El Borracho]

Pump...dump...gotta admire textbook execution...hilarious. Thanks for the joke thread @dachopper.

 

[Zonker]

Be curious how much dachopper lost. Feel like disclosing?

 

[TheDragon]

Pretty good pump and dump, but nowhere as good as Kodak.

 

[Miffy]

good to know even with covid, the bullshit smell detector still works even if you can’t smell or taste anything. 

 

[SCARECROW]

good to know even with covid, the bullshit smell detector still works even if you can’t smell or taste anything. 

If it starts to let you down I’ve been hearing about a great Stem cell based treatment for failed bullshit smell detectors. It’s still in the prelim testing stage and they’re looking for investors but initial results are promising and data will be out soon.

 

[Albatros]

If it starts to let you down I’ve been hearing about a great Stem cell based treatment for failed bullshit smell detectors. It’s still in the prelim testing stage and they’re looking for investors but initial results are promising and data will be out soon. is imminent

FIFY

 

[dachopper]

Topline results finally out. 75% reduction mortality in under 65's with dexamethazone, 46% reduction without using dexamethazone...

So it looks like it works, they will probably modify the dose or frequency for over 65's and get better results.

 

[dachopper]

Topline results finally out. 75% reduction mortality in under 65's with dexamethazone, 46% reduction without using dexamethazone...

So it looks like it works, they will probably modify the dose or frequency for over 65's and get better results.

Or to be clearer... in the study done using dexamethazone on ventilated patients, dexamethazone + standard of care reduced mortality by approx 30%. Mesoblast treatment without dexamethazone but with standard of care reduced mortality by around 45%  while mesoblast with dexamethazone and standard of care showed around a 75% reduction in mortality compared to the placebo arm with standard of care without mesoblast and without dexamethazone.

This is fantastic news. I'm hoping they can get approval for a phase 4 to vary the dose and get even better confirmatory results in the over and under 65's. From what I understand they only administered 2 doses of the therapy, whereas the gvhd doseage is 3 or more of 2 doses over time, repeated as directed.

 

[Albatros]

 I'm hoping they can get approval for a phase 4

imminent, soon, sooner, soonest

 

[El Borracho]

I've been doing some research on the potential ways out of this lockdown mess and back to normality, and discovered the little Aussie company that could ( Mesoblast ) - are in the middle of a US trial that looks like it's as close to a guaranteed done deal in reducing Covid caused deaths as you can get before a trial end date. They have a treatment of cells that they were in the final  stages of getting approved for use in the USA targeting steroid refractive Graft verses Host disease - which there is no treatment for, and has all ready shown fantastic results ( GVHD is where your own immune system attacks / kills you after receiving a transplant. Steroids are the only treatment but they do not work in about 40% of cases   ). 

As it turns out - the main killing mechanism they observe from Covid , appears to be the Hyper immune response, and the body killing itself also ( cytokine storm ).

So far they have treated 12 people on compassionate grounds who were seriously ill, on ventilators, some with multiple organ failure, some on ventilators for 2 weeks solid prior to being treated, and had a recovery rate of 83% or 10 / 12 people.. The recovery rate in the hospital during that same period for ventilated patients was under 12% ( 88% died ).

They are now about 1 week into the final trial that is necessary to prove that the treatment works, as a proper medical trial with patients getting treated with maximum care standard + either placebo or the cells. The trial has a primary endpoint of survival at 30 days, and also at 7 and 14 days along with other measurements. 33% of the way through the trial, if it is observed that the treatment is overwhelming effective ( which is expected by the compassionate use and other data ) - Then the FDA can approve immediate treatment before the trial has completed.

What is interesting is that Mesoblast by co-incidence were already ramping up production of the cells massively in preparation of their US product launch Ryoncil, and they have stated that they are in a good position to be capable of treating as many critical patents as is needed.

They also have some different cells that are completing their last phase 3 trial next month for lower back pain ( disc regeneration ) / and heart failure which also both look like they are primed for excellent results. 

If they show with the large trial what they did with the 12 critically ill patients, then we are going to be reducing COVID deaths to a level lower than seasonal Flu.... Also the product can treat seasonal Flu aswell..... Fingers crossed we here good news by the end of the month. or some time in June.  

Heh. One year -46%. Burning cash. Imminent nothing. On the plus side they seem to have quit the pump-and-dump scheme.