The Third Booster Shot Debate - Are U going to get the booster?

[EYESAILOR]

For those of you who are vaccinated, what do you think?

Are you going to take the booster shot?

Obviously there has been no trial on effect of the booster shot. Pfizer has indicated that it thinks the vaccine starts to fade around 4-6 months. CDC has pushed back on that saying insufficient evidence.  

Im not sure how they conduct a meaningful trial. In theory they would need to take a very large sample of people, giving half the placebo and half a booster shot and see how the numbers hold up vs Delta variant, but they would need to do that very soon.

I never got a certificate due to poor record keeping by hospital so Im thinking about the booster.

 

[IStream]

I'll be monitoring the breakthrough infection rate. If it goes up disproportionately versus the infection rate in the unvaccinated, that's evidence of fading vaccine effectiveness. Absent that and in the absence of 3rd shot efficacy data, I see no compelling reason to get a third shot of the same design as the first two. On the other hand, if they come out with a booster that's actually tailored to Delta, I'll get it. 

 

[shaggy]

Yes

 

[dogwatch]

Im not sure how they conduct a meaningful trial.

They don't need to. There have already been trials on safety and efficacy. As far as ex-post monitoring on efficacy, there is a ton of monitoring in the UK of who reports getting Covid and when they have been vaccinated is on record. Doubtless the same is true in many countries.

It is likely in the UK that Covid boosters and flu vaccines will be offered in one appointment and yes, I will accept. 

 

[jerseyguy]

Absolutely yes

 

[NeedAClew]

You bet. Sorry WHO. 

 

[TheDragon]

Happy to get a booster right now. Been 7 months since my first shot, 5 since my second.

 

[d'ranger]

Yes. Hope that if it's needed they will have tailored to help with delta, lambda and whatever else continues to mutate.

 

[Gangbusters]

Yes, maybe it comes with windows 11.

 

[accnick]

Yes. Fully Pfizered in late February, but I expect to look for a booster when we get back to FL in October.

My wife and I are both well past 70, and FL is unsafe at any speed, with a hands-off governor who is unwilling to do what it takes to minimize risks to state residents.

We were looking forward to some sense of normality this winter, but it seems like that really isn’t on the agenda.

 

[coyotepup]

I'll be monitoring the breakthrough infection rate. If it goes up disproportionately versus the infection rate in the unvaccinated, that's evidence of fading vaccine effectiveness. Absent that and in the absence of 3rd shot efficacy data, I see no compelling reason to get a third shot of the same design as the first two. On the other hand, if they come out with a booster that's actually tailored to Delta, I'll get it. 

Agreed, let's see if a booster shot is actually necessary or if people just want us to take it because it seems like it feels safer.  The data for the first two shots is beyond compelling to the point of being just about ironclad.  I was Modernafied, so if Moderna comes out and says "here is a booster that works on Delta (and maybe other variants too) in a very meaningful way" then I'll take it.  But the data needs to be similarly compelling, or at least approach it.  I don't want a shot just for the sake of a shot.

 

[IPLore]

I am torn. I had almost no reaction to the second jab, so I would not mind getting boosted to enure I have an immune reaction.

I moved from community health to getting further vaccinated to take care of #1. It is very disappointing that the vaccine starts to fade after 6 months. I really do not see how we can posibly produce enough vaccine, the world over to top everyone up every 6 months.  I am hoping it worlks like the 2nd jab.....the 3rd jab gives one even longer immunity....maybe like 18 months.

No data on all of this.

 

[IPLore]

They don't need to. There have already been trials on safety and efficacy. As far as ex-post monitoring on efficacy, there is a ton of monitoring in the UK of who reports getting Covid and when they have been vaccinated is on record. Doubtless the same is true in many countries.

It is likely in the UK that Covid boosters and flu vaccines will be offered in one appointment and yes, I will accept. 

Safety is not the issue. The data on safety only gets stronger as the vaccinated population gets larger. If there were advers e side effects that we didnt already know about (isloted cases of myocarditis which resolve themselves quickly) then Im sure we would have heard about them by now.

 

[Steam Flyer]

I'm willing to get a booster, when more of the world gets access to the vaccine and there is credible reporting... like from the CDC and such... that it's got definite benefit.

For now, I think talk of boosters and 3rd shots is kind of getting ahead of ourselves.

- DSK

 

[weightless]

when more of the world gets access to the vaccine and there is credible reporting... like from the CDC and such... that it's got definite benefit.

I think the equity issue is very important. Of course, logistics will be what they are and there's no point in dumping "excess" doses one place because there aren't enough doses someplace else.

I'm also looking to the CDC. However, I'm mindful that the director went all in with the "vaccinated don't get or transmit" in April and may have been using her influence to support that position. She took some reputation damage right away when the CDC publicly corrected technical errors in her assertion and I get the feeling there has been some reaction. However that may be, I gather that the CDC shut down their tracking database on breakthrough cases in May. So, the CDC hasn't collected as complete data as the some other countries eg. UK and Israel. Pfizer is an interested party but given that they're reporting on a sustantial Israeli database I think it's plausible that they're ahead of the CDC on the science and they aren't slowed down by a need to reverse prior positions.

 

[d'ranger]

I am torn. I had almost no reaction to the second jab, so I would not mind getting boosted to enure I have an immune reaction.

I moved from community health to getting further vaccinated to take care of #1. It is very disappointing that the vaccine starts to fade after 6 months. I really do not see how we can posibly produce enough vaccine, the world over to top everyone up every 6 months.  I am hoping it worlks like the 2nd jab.....the 3rd jab gives one even longer immunity....maybe like 18 months.

No data on all of this.

I posted a link somewhere about current trials in India of a vaccine developed in Houston by Dr Peter Hotez and and someone whose name I can't remember- easy to produce and store and cheap - $1.50 a pop.  The article mentions there are about 100 others in developments or trials around the world.  If the Houston one gets approved it has the additional benefit of extremely low side effects.  The only thing stopping us now is ourselves. 

That vaccine has been under development (much like the ones out now) for years before Covid showed up.  And if the good doctor was based in LA or SF we could call it the Hotez California, check it out.

 

[12 metre]

A day After the AZ I began experiencing what I believe is small fiber neuropathy which worsened after the followup Moderna a month ago. 

It's not the end of the world and seems to be improving the past few days, but it is a bit debilitating.  I will discuss with my GP via phone next Monday.

Anyways, I am very much at the wait and see point right now due to the apparent side effect I have experienced.  But at this point - probably not.

Also, as has been pointed out, it would be a much better use of vaccine if we can get it into the arms of people in third world countries before allowing us to indulge in a 3rd round of vaccine.

Of course this is dependent on the vaccines not falling into the wrong hands in third world countries and ending up on the black market.

 

[Steam Flyer]

A day After the AZ I began experiencing what I believe is small fiber neuropathy which worsened after the followup Moderna a month ago. 

It's not the end of the world and seems to be improving the past few days, but it is a bit debilitating.  I will discuss with my GP via phone next Monday.

Anyways, I am very much at the wait and see point right now due to the apparent side effect I have experienced.  But at this point - probably not.

Ouch... sorry to hear about that... hope it's not related and clears up

- DSK

 

[IPLore]

I think the equity issue is very important. Of course, logistics will be what they are and there's no point in dumping "excess" doses one place because there aren't enough doses someplace else.

I'm also looking to the CDC. However, I'm mindful that the director went all in with the "vaccinated don't get or transmit" in April and may have been using her influence to support that position. She took some reputation damage right away when the CDC publicly corrected technical errors in her assertion and I get the feeling there has been some reaction. However that may be, I gather that the CDC shut down their tracking database on breakthrough cases in May. So, the CDC hasn't collected as complete data as the some other countries eg. UK and Israel. Pfizer is an interested party but given that they're reporting on a sustantial Israeli database I think it's plausible that they're ahead of the CDC on the science and they aren't slowed down by a need to reverse prior positions.

Pfizer does have a commercial interest but I honestly dont think that Pfizer's comment is driven by commercial interest. Right now, they can sell all the vaccine they can produce as fast as they can produce it.  In the longer term, the commercial winner will be the vaccine with the longest lifespan and greatest efficacy.  If Moderna's vaccine lasts 12 months before decline and Pfizers last 6 months, then Moderna will end up with 100% market share and Pfizer 0%.   So if Pfizer is talking about a booster, it is because they want to make sure their vaccine is effective.

I am a moderna vaxx . I will wait and see for another 3-4 weeks but then I will take action.